tag:blogger.com,1999:blog-8386055846297828307.post5434760595743270383..comments2024-03-28T07:34:49.133+01:00Comments on The Genealogical World of Phylogenetic Networks: James Bond, alcoholicUnknownnoreply@blogger.comBlogger3125tag:blogger.com,1999:blog-8386055846297828307.post-46608794500734132702016-12-26T02:52:40.755+01:002016-12-26T02:52:40.755+01:00SEE THIS RELATED ARTICLEZ . . .
From Science Dail...SEE THIS RELATED ARTICLEZ . . .<br /><br />From Science Daily<br />(May 10, 2006):<br /><br />“How Drug Binds To Neurons<br />To Stop Drunken Symptoms Of Alcohol”<br /><br />Link: http://www.sciencedaily.com/releases/2006/05/060510192138.htm<br /><br />UCLA researchers discovered how an experimental drug, called Ro15-4513, binds to specific receptors on brain neurons, which helps explain how this drug stops the drunken behavioral symptoms of alcohol such as impaired motor coordination, memory loss and drowsiness.<br /><br />The team showed in the lab that Ro15-4513 binds to and blocks alcohol action on these highly alcohol-sensitive receptors. The UCLA group previously found that these receptors are specific subtypes of Gamma-amino butyric acid (GABA-A) receptors that play a role in impairing motor coordination caused by alcohol in experimental animals.<br /><br />These studies are the first to show how the alcohol antidote drug Ro15-4513 binds to these GABA-A receptors. The research may lead to a better understanding of how alcohol works in the brain as well as help develop drugs that prevent alcohol actions such as a sober-up pill, and alcohol addiction medications and treatments. UCLA researchers also suggest in the future that it may be possible to harness the beneficial effects of alcohol on the body, including inducing sleep, enhancing mood or mirroring the positive effects of moderate alcohol consumption on the heart and brain.<br /><br />Authors of the study include Richard W. Olsen, Ph.D., professor and Martin Wallner, Ph.D., researcher, both in the UCLA Department of Molecular and Medical Pharmacology. The research appears in the May 8 online edition of the Proceedings of the National Academy of Sciences.<br /><br />The study was funded by the National Institutes of Health, the Alcoholic Beverage Medical Research Foundation, and the State of California for medical research on alcohol and substance abuse.<br />Bob Henryhttps://www.blogger.com/profile/02089688073031173053noreply@blogger.comtag:blogger.com,1999:blog-8386055846297828307.post-37413563113159731222016-12-26T02:52:27.155+01:002016-12-26T02:52:27.155+01:00SEE THIS RELATED ARTICLE . . .
Excerpt from the L...SEE THIS RELATED ARTICLE . . .<br /><br />Excerpt from the Los Angeles Times<br />(January 6, 1987, Page Unknown):<br /><br />“The Sad Fate of a Swiss Sober-Up Pill"<br /><br />[Link: not available]<br /><br />By John Brennan<br />"Your Prescriptions" Column<br /><br />As we celebrated the New Year with parties, many livened up by drinking alcoholic beverages. What would be better to contemplate than to be able to drink one's fill, then take a tablet and, presto, become sober again. Such a drug is on the horizon and it is now known only by its code name, Ro15-4513.<br /><br />About three years ago, pharmaceutical chemists of the giant Swiss company, Hoffman LaRoche, discovered this drug . . .<br /><br />. . .<br /><br />To confirm these findings, Drs. Peter Suzdak, John Glowa, Jaqueline Crawley, Rochelle Schwartz, Phil Skolnick and Steven Paul of the U.S. National Institutes of Health repeated the experiments. Not only were the original observations of the effects of Ro15-4513 confirmed, the mechanism of the action of the drug was clearly delineated.<br /><br />. . .Bob Henryhttps://www.blogger.com/profile/02089688073031173053noreply@blogger.comtag:blogger.com,1999:blog-8386055846297828307.post-43150754606792584052016-12-26T02:51:52.265+01:002016-12-26T02:51:52.265+01:00Perhaps Mr. Bond had some pharmaceutical help?
Ex...Perhaps Mr. Bond had some pharmaceutical help?<br /><br />Excerpt from New York Times “U.S.” Section<br />(November 28, 1986, Page Unknown):<br /><br />“Tests Said to Show New Drug Reverses Intoxication”<br /><br />http://www.nytimes.com/1986/11/28/us/tests-said-to-show-new-drug-reverses-intoxication.html?pagewanted=print<br /><br />By Associated Press<br /><br />Government researchers are testing a drug that quickly reverses or prevents the intoxicating effects of alcohol, and they say it could potentially be used to sober up drunken people or to treat those who suffer from alcoholism.<br /><br />While the researchers acknowledge that the substance offers a quick way to become immediately sober for those who drink too much, the researchers say ethical and legal considerations may stand in its way.<br /><br />Scientists at the National Institute of Mental Health, in a paper to be published in the next issue of the journal Science, say the substance, a synthetic compound, blocks the intoxicating and inhibition-erasing effects of alcohol in rats.<br /><br />However, Dr. Peter D. Suzdak, principal author of the paper, said in an interview that the drug neither lowers the levels of alcohol in the body nor affects other aspects of alcohol overdose, such as respiratory depression or coma.<br /><br />"We have a drug that appears to block some of the effects of ethanol," Dr. Suzdak said, using another term for grain alcohol, "but by no means do we imply that it will block all the effects."<br /><br />Tests on Primates Starting<br /><br />The most obvious use of the drug, if it is proved effective for humans, would be in treating alcoholics, he said, adding that tests of the compound on nonhuman primates were just beginning.<br /><br />"The drug probably has many clinical implications," Dr. Suzdak said. "Using it, we may be able to find out what makes an alcoholic drink, the anti-inhibitory effects, anti-anxiety effects, whatever. If the compound then blocks these reinforcing effects, we might have a drug that could be used to treat alcoholic patients." He noted that an opiate-blocking agent, Naltrexone, was being used to treat heroin addicts.<br /><br />While there is a huge commercial potential for a drug that would quickly sober up people, Dr. Suzdak said such a drug could encourage people to drink to excess, leaving them vulnerable to the alcoholic effects that the compound does not block, or a manufacturer could be legally liable in cases where the drug did not work or if a person who had used it was involved in a fatal accident.<br /><br />Because of these potential problems, Dr. Suzdak said, "Probably the only clinical use the Food and Drug Administration would approve it for would be to treat alcoholism."Bob Henryhttps://www.blogger.com/profile/02089688073031173053noreply@blogger.com